kim
ideas were not enough: locke, spinoza and voltaire were all brilliant, but religious freedom in europe was driven by statecraft not philosophy
mark koyama 2017
aeon.co/essays/the-modern-state-not-ideas-brought-about-religious-freedom
the craving mind: from cigarettes to smartphones to love—why we get hooked and how we can break bad habits
judson brewer 2017 9780300223248
the hacking of the american mind: the science behind the corporate takeover of our bodies and brains
robert lustig 2017 to read next
zero zero zero
robert saviano 2015 9781594205507
warning: author may be dodgy
chasing the scream: the first and last days of the war on drugs
johann hari 2014 9781620408926
lost connections: uncovering the real causes of depression – and the unexpected solutions
johann hari 2017 to read next
politics and economic stratification: power resources and income inequality in the united states
david jacobs, jonathan c. dirlam 2016
687744
how the mafia is causing cancer
ian birrell 2016
Link: mosaicscience.com/story/how-mafia-causing-cancer
sicily’s mafia sprang from the growing global market for lemons – a tale with sour parallels for consumers today
ola olsson 2018
https://aeon.co/essays/how-a-growing-market-for-citrus-fruit-spawned-the-mafia
lensman series and others
e. e. smith
politics of racism: the uprooting of japanese canadians during the second world war
ann gomer sunahara 2000
how racism is made, and unmade
charles lindley 2017
stigma by prejudice transfer
diana t. sanchez, kimberly e. chaney, sara k. manuel, leigh s. wilton, jessica d. remedios 2017
0956797616686218
science doesn’t explain tech’s diversity problem — history does: you can’t fix something by ignoring it
sarah jeong and rachel becker 2017
theverge.com/2017/8/16/16153740/tech-diversity-problem-science-history-explainer-inequality
cannabis use and hypomania in young people: a prospective analysis
steven marwaha et al. 2017
http://dx.doi.org/10.1093/schbul/sbx158
market structure leading to distribution
illicit fentanyls in the opioid street market: desired or imposed?
sarah g. mars et al. 2018
http://dx.doi.org/10.1111/add.14474
First synthesized in a Belgian lab in 1960, illicitly produced fentanyl has swept through U.S. drug markets in waves, the latest beginning in 2013, and has claimed an extraordinary number of lives. The researchers who wrote the report said having a better understanding of whether fentanyl's deadly spread is being driven by the economic imperatives of suppliers or the tastes of drug users would help policymakers find ways to curb it.
Made entirely in the lab, fentanyl is far more powerful and much cheaper to produce than heroin, which is derived from poppy opium. It is usually sold deceptively -- as heroin or brand name prescription drugs like OxyContin and Xanax. The researchers said drug users and street-level dealers, who may also be using the drugs, often don't know whether they are taking or selling drugs adulterated with fentanyl, since it is added to the supply higher up the distribution chain. Therefore, the researchers said, demand from drug users is unlikely to have played a role in its spread.
"Fentanyl is rarely sold as fentanyl," said Sarah Mars, PhD, a researcher in the Department of Family and Community Medicine at UCSF and the first author of the paper, published Tuesday, Dec. 4, in Addiction. "The dealers selling fentanyl directly to the users often don't know what's in it. Not only is this particularly dangerous, but it also means penalizing low level dealers isn't going to make any difference in the fentanyl poisoning epidemic."
The researchers sifted through the scientific literature on fentanyl use, pored over United Nations opium production data as well as data on heroin price and purity from the U.S. Drug Enforcement Administration, and analyzed results from their ongoing NIH-funded study, Heroin in Transition, which is led by senior author Daniel Ciccarone, MD, MPH, a professor of family and community medicine at UCSF.
"Our research has focused on talking to people who are using heroin and fentanyl-laced heroin, and asking them about their experiences," said Mars, who directs the study's qualitative research. "Most of the illicit fentanyl has been in the Northeast and Midwest, and we've been to places where the death rate is very high. We asked drug users how they detect it, if they can -- how they try to prevent overdose."
Mars said users expressed opposing views on fentanyl, which causes a more sudden and powerful but usually shorter high than heroin. While some said they liked fentanyl, because it brought on the euphoria they had lost the ability to feel from tolerance built up by long-term heroin use, or because it broke through the opioid blocking effects of medications like buprenorphine, others said they feared fentanyl and disliked its harsh effects.
"Whether or not they prefer fentanyl, users don't have any influence over what drugs are being sold," Mars said. "Without accurate information about these drugs, they can't make an informed choice about what they are buying. Also, very little drug slang has developed to describe fentanyl, which lends support to the notion that this is not a demand-driven epidemic."
The researchers said users do try in various ways to detect fentanyl in the drugs they buy, but it's impossible for them to determine which synthetic opioid is present or how potent it is before they use it.
Different chemical versions of fentanyl, known as analogues, with wildly varying potency, appear unpredictably in different locations around the country. Some analogues are so new they have not yet been deemed illegal and some, like carfentanil, which was designed to tranquilize large animals, are incredibly powerful -- as much as 10,000 times the strength of morphine.
"We believe it's the fluctuation in the potency of the drugs containing fentanyl that makes them so dangerous," Ciccarone said. "You might have one dose that had hardly any fentanyl in it or none at all. Then, you might have one with a different fentanyl analogue, of different potency, or even mixtures of multiple fentanyls and heroin."
The researchers said the data suggest that heroin shortages or 'supply shocks' occurred before the current and prior fentanyl waves struck in both Europe and the U.S. Prescription opioids were also becoming harder to obtain in the U.S. at the time. Fentanyl, which has also appeared in drug markets in many European countries, as well as Russia, Brazil and Canada, is an easy substitute for heroin since it can be produced in the lab year round and is not subject to blight, pests or climate conditions. It is about 30 to 40 times stronger than heroin and considerably cheaper to produce.
The full motives of wholesale suppliers still remain hidden, but there are significant incentives for them to shift over partially or completely to fentanyl, even though it often causes users to overdose. The researchers said it may just be a matter of time before fentanyl takes over more of the illicit U.S. and worldwide drug market, as has already happened in Estonia.
abstract
Background
Illicitly manufactured fentanyl and its analogues are appearing in countries throughout the world, often disguised as heroin or counterfeit prescription pills, with resulting high overdose mortality. Possible explanations for this phenomenon include reduced costs and risks to heroin suppliers, heroin shortages, user preferences for a strong, fast‐acting opioid and the emergence of Dark Web cryptomarkets. This paper addresses these potential causes and asks three questions: (1) can users identify fentanyl; (2) do users desire fentanyl; and (3) if users want fentanyl, can they express this demand in a way that influences the supply?
Argument/analysis
Existing evidence, while limited, suggests that some users can identify fentanyl, although not reliably, and some desire it, but because fentanyl is frequently marketed deceptively as other drugs, users lack information and choice to express demand effectively. Even when aware of fentanyl's presence, drug users may lack fentanyl‐free alternatives. Cryptomarkets, while difficult to quantify, appear to offer buyers greater information and competition than offline markets. However, access barriers and patterns of fentanyl‐related health consequences make cryptomarkets unlikely sources of user influence on the fentanyl supply. Market condition data indicate heroin supply shocks and shortages prior to the introduction of fentanyl in the United States and parts of Europe, but the much lower production cost of fentanyl compared with heroin may be a more significant factor
Conclusion
Current evidence points to a supply‐led addition of fentanyl to the drug market in response to heroin supply shocks and shortages, changing prescription opioid availability and/or reduced costs and risks to suppliers. Current drug users in affected regions of the United States, Canada and Europe appear largely to lack both concrete knowledge of fentanyl's presence in the drugs they buy and access to fentanyl‐free alternatives.
association of maternal and paternal depression in the postnatal period with offspring depression at age 18 years
leticia gutierrez-galve et al. 2018
http://dx.doi.org/10.1001/jamapsychiatry.2018.3667
Almost one in 20 new fathers suffered depression in the weeks after their child was born, according to a study published in the journal JAMA Psychiatry and co-authored by Professor Paul Ramchandani of the Faculty of Education, University of Cambridge.
The research, based on a sample of more than 3,000 families in Bristol, UK, also identified a link between post-natal depression in men and depression in their daughters as they reached adulthood.
At 18, girls whose fathers had experienced depression after their birth were themselves at greater risk of the condition, researchers found. The "small but significant" increased risk applied only to daughters; sons were not affected.
One reason for this "handing on" effect could be that post-natal depression in fathers is sometimes linked with an increased level of maternal depression, researchers concluded. This might mean that family life is more disrupted for everyone with higher levels of stress for all. It may also be that the having one or both parents with depression affects the way in which parents interact with their children.
It is unclear why girls may be more affected at this age. There may be links to specific aspects of father-daughter relationships as girls go through adolescence, the research team suggests.
The findings are important because they have implications for perinatal services, which have traditionally considered post-natal depression to be a potential problem for mothers only, the study's authors say. They highlight the importance of recognising and treating depression in fathers during the postnatal period, and call on health professionals to consider both parents when one reports depression.
Professor Ramchandani said: "Research from this study of families in Bristol has already shown that fathers can experience depression in the postnatal period as well as mothers. What is new in this paper is that we were able to follow up the young people from birth through to the age of 18, when they were interviewed about their own experience of depression. Those young people whose fathers had been depressed back when they were born had an increased risk of depression at age 18 years.
"We were also able to look at some of the ways in which depression in fathers might have affected children. It appears that depression in fathers is linked with an increased level of stress in the whole family, and that this might be one way in which offspring may be affected.
"Whilst many children will not be affected by parental depression in this way, the findings of this study highlight the importance of providing appropriate help to fathers, as well as mothers, who may experience depression."
Paternal depression campaigner Mark Williams, who set up the lobby group Fathers Reaching Out and campaigns for mental health screening for new fathers as well as mothers, said: "Fathers' Postnatal Depression impacts on the whole family when unsupported, often resulting in fathers using negative coping skills, avoiding situations and often feeling anger.
"In my experience of working with families, it's sometimes only the father who is suffering in silence but sadly very few are asked about their mental health after becoming a parent."
Earlier research by the same academic team found post-natal depression in fathers was linked to behavioural and emotional problems in their children at three and a half and seven. The effect seems to happen because paternal depression may negatively affect the way a family functions -- causing conflict between partners and prompting maternal depression.
The new paper, Association of Maternal and Paternal Depression in the Postnatal Period with Offspring Depression at Age 18 Years, was based on the experiences of 3,176 father and child pairs drawn from the Avon Longitudinal Study of Parents and Children -- an ongoing cohort study launched in 1991.
abstract Question What are the mechanisms of risk transmission from paternal depression during the postnatal period to offspring depression at age 18 years?
Findings In this cohort study of 3176 father-offspring pairs, paternal depression in the postnatal period was associated with offspring depression at age 18 years and appears to exert its influence on later emotional problems in female children partially through maternal depression. Early conduct disorder in children appears to be a mechanism of risk transmission.
Meaning Depression in fathers in the postnatal period has potential implications for family and child functioning into late childhood and adolescence; it should be addressed in perinatal services, and both parents should be considered when 1 presents with depression.
Abstract
Importance Paternal depression during the postnatal period has been associated with adverse child outcomes. Family environment has been reported as a pathway for risk transmission from fathers to children. The influence of paternal depression during the postnatal period on offspring depression remains to be clarified.
Objective To investigate the association between paternal depression in the postnatal period and offspring depression and explore potential mediating and moderating factors that influence any association between paternal and offspring depression.
Design, Setting, and Participants This prospective study of a UK community-based birth cohort (the Avon Longitudinal Study of Parents and Children) of parents and their adolescent offspring investigated associations between paternal depression during the postnatal period and offspring depression at age 18 years. We tested a hypothesized moderator (ie, sex) and conducted path analysis to examine hypothesized mediators (ie, depression in the other parent, couple conflict, and paternal involvement and emotional problems, conduct problems, and hyperactivity in offspring at age 3.5 years) of the associations between both paternal and maternal depression and offspring depression. Data collection for the Avon Longitudinal Study of Parents and Children began in 1991 and is ongoing. Data analysis for this study was conducted from June 2015 to September 2018.
Exposures Depression symptoms in fathers at 8 weeks after the birth of their children.
Main Outcomes and Measures Offspring depression symptoms at age 18 years, using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes.
Results A total of 3176 father-offspring pairs were analyzed; of the children, 1764 were girls (55.5%) and 1412 (44.5%) were boys. Paternal mean (SD) age at delivery was 29.6 (9.6) years. The offspring of fathers who had depression during the postnatal period were at increased risk of experiencing depression symptoms at age 18 years (β = 0.053 [95% CI, 0.02-0.09]). The association is mediated by maternal depression at 8 months after birth (β = 0.011 [95% CI, 0.0008-0.02]; 21% [0.011/0.053]) and conduct problems at 42 months after birth (β = 0.004; [95% CI , −0.00004 to 0.009]; 7.5% [0.004/0.053]). Couple conflict and paternal involvement do not mediate this association. The increased risk is seen in girls but not boys (interaction β = 0.095; P = .01).
Conclusions and Relevance The association between paternal depression in the postnatal period and depression in girls at age 18 years is partially explained by maternal depression. Couple conflict and paternal involvement were not found to play a role in the risk of transmission; this contrasts with the role that couple conflict was found to play in the risk of childhood behavior problems. Conduct problems in childhood appear to be a pathway for risk transmission between paternal depression and subsequent depression in offspring at age 18 years.
winter tide
ruthanna emrys 2017
deep roots
ruthanna emrys 2018
honor among thieves
rachel caine 2018
stars uncharted
s.k. dunstall 2018
linesman
s.k. dunstall 2015
fool’s gold
jon hollins 2016
false idols
jon hollins 2017
bad faith
jon hollins 2018
noumenon
marina j lostetter 2018
touching infinity
erin hayes 2017
fear less: living beyond fear, anxiety, anger, and addiction
dean sluyter 2018
the pleasure instinct: why we crave adventure, chocolate, pheromones, and music
gene wallenstein 2008
the fear factor: how one emotion connects altruists, psychopaths, and everyone in-between
abigail marsh 2017
how to change your mind: what the new science of psychedelics teaches us about consciousness, dying, addiction, depression, and transcendence
michael pollan 2018
boney m
west cork ukulele orchestra
Link: m.youtube.com/watch
the crazy rutcheon team
Link: m.youtube.com/watch
there lived a certain man in russia long ago
he was big and strong, in his eyes a flaming glow
most people looked at him with terror and with fear
but to moscow chicks he was such a lovely dear
he could preach the bible like a preacher
full of ecstasy and fire
but he also was the kind of teacher
women would desire
ra ra rasputin
lover of the russian queen
there was a cat that really was gone
ra ra rasputin
russia's greatest love machine
it was a shame how he carried on
he ruled the russian land and never mind the czar
but the kazachok he danced really wunderbar
in all affairs of state he was the man to please
but he was real great when he had a girl to squeeze
for the queen he was no wheeler dealer
though she'd heard the things he'd done
she believed he was a holy healer
who would heal her son
ra ra rasputin
lover of the russian queen
there was a cat that really was gone
ra ra rasputin
russia's greatest love machine
it was a shame how he carried on
but when his drinking and lusting and his hunger
for power became known to more and more people
the demands to do something about this outrageous man became louder and louder
this man's just got to go, declared his enemies
but the ladies begged, don't you try to do it, please
no doubt this rasputin had lots of hidden charms
though he was a brute they just fell into his arms
then one night some men of higher standing
set a trap, they're not to blame
come to visit us they kept demanding
and he really came
ra ra rasputin
lover of the russian queen
they put some poison into his wine
ra ra rasputin
russia's greatest love machine
he drank it all and said, i feel fine
ra ra rasputin
lover of the russian queen
they didn't quit, they wanted his head
ra ra rasputin
russia's greatest love machine
and so they shot him 'til he was dead
oh, those russians
hierarchical organisations are inherently abusive because it is so easy for abusive people to take control of them
I always try to go through official channels first. however I don't have much expectation that official channels will work. all it takes is one irresponsible person, a weak link in the chain of command, and the channel is scuppered.
thus always have backup plans and sometimes even reliable channels for the essential things that must get through.
chabuduo! close enough ...
your balcony fell off? chabuduo. vaccines are overheated? chabuduo. how china became the land of disastrous corner-cutting
james palmer 2016
what-chinese-corner-cutting-reveals-about-modernity
Link: aeon.co/essays/what-chinese-corner-cutting-reveals-about-modernity
when all it takes is one person who dislikes you, often from prejudice rather than from knowing you