rinna
peak: how all of us can achieve extraordinary things
anders ericsson, robert pool 2017
born to run: a hidden tribe, superathletes, and the greatest race the world has never seen
christopher mcdougall
evoking the ineffable: the phenomenology of extreme sports
eric brymer, robert d. schweitzer 2017
dx.doi.org/10.1037/cns0000111
extreme sports as invigorating experience, inadequacy of words, and participants’ experience of transcendence.
We explored an aspect of the life-world of extreme sports participants from a phenomeno-logical perspective. We focused on describing the ineffable element of the extreme sport ex-perience. However, any attempt to describe the indescribable immediately reduces the intensity and power of such an experience to defined, bound verbalizations and conceptualizations. Attempts to clarify certain experiences poten-tially results in the experience being lost, or, perhaps worse still, being obliterated in the pro-cess. A contemporary phenomenologist, van
71 EVOKING THE INEFFABLE
tardigrades use intrinsically disordered proteins to survive desiccation
boothby et al. 2017
dx.doi.org/10.1016/j.molcel.2017.02.018
•Tardigrade intrinsically disordered proteins (TDPs) are enriched during desiccation
•TDPs are required for tardigrades to survive desiccation
•Expression of TDPs increases desiccation tolerance in heterologous systems
•TDPs vitrify, and this vitrified state mirrors their protective capabilities
Tardigrades are microscopic animals that survive a remarkable array of stresses, including desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 years. Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation. Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance. TDP genes are constitutively expressed at high levels or induced during desiccation in multiple tardigrade species. TDPs are required for tardigrade desiccation tolerance, and these genes are sufficient to increase desiccation tolerance when expressed in heterologous systems. TDPs form non-crystalline amorphous solids (vitrify) upon desiccation, and this vitrified state mirrors their protective capabilities. Our study identifies TDPs as functional mediators of tardigrade desiccation tolerance, expanding our knowledge of the roles and diversity of disordered proteins involved in stress tolerance.
hormetic heat stress and hsf-1 induce autophagy to improve survival and proteostasis in c. elegans
caroline kumsta, jessica t. chang, jessica schmalz, malene hansen 2017
ncomms14337
allegory versus literal interpretation
musical structure of plato's dialogues
j. b. kennedy 2011
Link: search.lib.cam.ac.uk/
i’d like to teach the world to sing
the new seekers
i’d like to build a world a home
and furnish it with love
grow apple trees and honey bees
and snow white turtle doves
i’d like to teach the world to sing
in perfect harmony
i’d like to hold it in my arms
and keep it company
i’d like to see the world for once
all standing hand in hand
and hear them echo through the hills
for peace throughout the land
it’s the real thing
what the world wants today
that’s the way it’ll stay
with the real thing
☆i’d like to teach the world to sing
in perfect harmony
a song of peace that echoes on
and never goes away
put your hand in my hand
let’s begin today
with your hand in my hand
help me find a way
i’d like to see the world for once
all standing hand in hand
and hear them echo through the hills
for peace throughout the land
☆repeat
lost in time and space: states of high arousal disrupt implicit acquisition of spatial and sequential context information
thomas maran et al. 2017
dx.doi.org/10.3389/fnbeh.2017.00206
endure: mind, body, and the curiously elastic limits of human performance
alex hutchinson 2018
extremes: life, death and the limits of the human body
kevin fong 2013
extreme medicine: how exploration transformed medicine in the twentieth century
kevin fong 2014
endgame, vol. 1: the problem of civilization
derrick jensen 2006
59 seconds: think a little, change a lot
richard wiseman 2010
the need for roots: prelude to a declaration of duties towards mankind
simone weil, arthur wills 1943, 2001
peak performance: elevate your game, avoid burnout, and thrive with the new science of success
brad stulberg, steve magness 2017
resilient: how to grow unshakable core of calm strength and happiness
rick hanson 2018
the impact code: live the life you deserve
nigel risner 2006
train your mind for peak performance: a science-based approach for achieving your goals
lyle bourne 2011