medical error—the third leading cause of death in the us
markary and daniel 2016
when evidence says no, but doctors say yes
david epstein and propublica 2017
mandrills use olfaction to socially avoid parasitized conspecifics
clémence poirotte et al. 2017
infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community
jing yan et al. 2018
major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
niharika arora duggal et al. 2018
properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years
ross d. pollock et al. 2018
a canary in the coalmine
relationships between urinary phthalate metabolite and bisphenol a concentrations and vitamin d levels in u.s. adults: national health and nutrition examination survey (nhanes), 2005–2010
lauren e. johns, kelly k. ferguson, john d. meeker 2016
I have low blood vitamin d despite healthy diet and sunshine exposure
I predict a relationship between pesticide exposure (roundup) and blood vitamin d
estimation of the dietary requirement for vitamin d in adolescents aged 14-18 y: a dose-response, double-blind, randomized placebo-controlled trial
t. j. smith et al 2016
determinants of the maternal 25-hydroxyvitamin d response to vitamin d supplementation during pregnancy
rebecca j. moon et al. 2016
footwear matters: influence of footwear and foot strike on load rates during running
rice hm, et al. 2016
differences in perceived causes of childhood obesity between migrant and local communities in china: a qualitative study
bai li et al. 2017
macrophage migration inhibitory factor is subjected to glucose modification and oxidation in alzheimer’s disease
omar kassaar et al. 2017
enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans
robinson et al. 2017
•High-intensity interval training improved age-related decline in muscle mitochondria •Training adaptations occurred with increased gene transcripts and ribosome proteins •Changes to RNA with training had little overlap with corresponding protein abundance •Enhanced ribosomal abundance and protein synthesis explain gains in mitochondria
The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic capacity and skeletal muscle mitochondrial respiration. HIIT revealed a more robust increase in gene transcripts than other exercise modalities, particularly in older adults, although little overlap with corresponding individual protein abundance was noted. HIIT reversed many age-related differences in the proteome, particularly of mitochondrial proteins in concert with increased mitochondrial protein synthesis. Both RT and HIIT enhanced proteins involved in translational machinery irrespective of age. Only small changes of methylation of DNA promoter regions were observed. We provide evidence for predominant exercise regulation at the translational level, enhancing translational capacity and proteome abundance to explain phenotypic gains in muscle mitochondrial function and hypertrophy in all ages.
orthostatic hypotension and the long-term risk of dementia: a population-based study
frank j. wolters, francesco u. s. mattace-raso, peter j. koudstaal, albert hofman, m. arfan ikram, heart brain connection collaborative research group
effect of restricted salt intake on nocturia
tomohiro, m., nakamura, y., yasuda, t., ohba, k., miyata, y., sakai, h 2017
smell loss predicts mortality risk regardless of dementia conversion
jonas olofsson et al. 2017
astrocytes regulate daily rhythms in the suprachiasmatic nucleus and behavior
chak foon tso et al. 2017
opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation
wang et al. 2016
zika–capable mosquitoes in washington dc
lima et al 2016
Published online November 2, 2015 , doi: 10.4269/ajtmh.15-0351 Am J Trop Med Hyg 2016 vol. 94 no. 1 231-235
assuming that a disease is limited by the “known range” of its known vectors is a mistake
travel.trade.gov visits to usa numbers
travel.trade.gov visits from usa numbers
refugees and asylees accepted by usa numbers
bacterial colonization and succession in a newly opened hospital
simon lax et al. 2017
bioelectric regulation of innate immune system function in regenerating and intact xenopus laevis
jean-françois paré, christopher j. martyniuk, michael levin 2017
c. elegans daf-16/foxo interacts with tgf-ß/bmp signaling to induce germline tumor formation via mtorc1 activation
wenjing qi et al. 2017
prebiotic reduces body fat and alters intestinal microbiota in children with overweight or obesity
alissa c. nicolucci et al. 2017
adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health
david a. raichlen, gene e. alexander 2017
classification of common human diseases derived from shared genetic and environmental determinants
kanix wang, hallie gaitsch, hoifung poon, nancy j cox, andrey rzhetsky 2017
high-intensity workouts won’t work for most people
the rachitic tooth: the use of radiographs as a screening technique
lori d’ortenzio et al. 2017
prion seeding activity and infectivity in skin samples from patients with sporadic creutzfeldt-jakob disease
christina d. orrú et al. 2017
exposure to magnetic field non-ionizing radiation and the risk of miscarriage: a prospective cohort study
de-kun li et al. 2017
association of modifiable risk factors in young adulthood with racial disparity in incident type 2 diabetes during middle adulthood
michael p. bancks et al. 2017
destructive disinfection of infected brood prevents systemic disease spread in ant colonies
christopher d pull et al. 2017
antithyroid drugs and congenital malformations
gi hyeon seo et al. 2018
note carbimazole (sold under brand name vidalta) after absorbtion is converted to the active form, methimazole.
elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 diabetes
alexandra moraru et al. 2018
if tuck chin in, impossible to snore?
chin jutting, impossible not to?
rarely have coughing caused by own nasal mucus anymore, because have learned to swallow it before it reaches the lungs.
simple muscle tension experiment: if place flat of palm of hand against conductive bone near ear, or on ear, at night, while head rests gently on palm — pillow useful for placement. if tense either muscles in arm or cheek, can hear the subtle vibrations as muscles act in dynamic tension, lack of vibration when all muscles relaxed.
can't promise that you'll never have a sore throat ever again, but I can promise that this will reduce the severity of the symptoms. Sore throats commonly occur when we are ill, and the symptom is a pain in the throat area. The pain comes because the upper airway, just below the epiglottis, has become drier, and the lining of the airway thus becomes more sensitive. Causes of the dryness could include illness slowing mucus production deeper in the lungs, or very dry air in the house or outside. The temporary solution, however, is easy — you can often relieve a painful sore throat in minutes — all you need to do is to swallow. Swallowing, without actually needing to swallow any food or water, is sufficient to encourage local mucus movement and production right where it is needed most. You may want to experiment with swallowing at different intervals or in different patterns.
Swallowing eases the symptom of a sore throat by encouraging wetter mucous from lungs to move faster towards the normal exit point of the oesophagus. Thus the dried out area of the trachea or throat which is hurting is covered by mucous and soothed temporarily.
Seems like common sense once you know it but seems slightly esoteric before you understand why it works
For a longer–term solution, drink water often enough to replenish your internal supplies so you can produce enough mucus to suit the air or illness. The only downside is that you'll no longer be able to complain about having a sore throat when you are ill, so people won't believe your illness is as bad as theirs!
prevent dry–air nosebleeds
wait for new thin film of wet mucous to form between dried mucous and nasal passage before attempting to blow out dried mucous from nose. if this means stifling sneezes for a little while, do so.
investigating the case of human nose shape and climate adaptation
arslan a. zaidi, brooke c. mattern, peter claes, brian mcecoy, cris hughes, mark d. shriver 2017
The evolutionary reasons for variation in nose shape across human populations have been subject to continuing debate. An import function of the nose and nasal cavity is to condition inspired air before it reaches the lower respiratory tract. For this reason, it is thought the observed differences in nose shape among populations are not simply the result of genetic drift, but may be adaptations to climate. To address the question of whether local adaptation to climate is responsible for nose shape divergence across populations, we use Qst–Fst comparisons to show that nares width and alar base width are more differentiated across populations than expected under genetic drift alone. To test whether this differentiation is due to climate adaptation, we compared the spatial distribution of these variables with the global distribution of temperature, absolute humidity, and relative humidity. We find that width of the nares is correlated with temperature and absolute humidity, but not with relative humidity. We conclude that some aspects of nose shape may indeed have been driven by local adaptation to climate. However, we think that this is a simplified explanation of a very complex evolutionary history, which possibly also involved other non-neutral forces such as sexual selection.
The study of human adaptation is essential to our understanding of disease etiology. Evolutionary investigations into why certain disease phenotypes such as sickle-cell anemia and lactose intolerance occur at different rates in different populations have led to a better understanding of the genetic and environmental risk factors involved. Similarly, research into the geographical distribution of skin pigmentation continues to yield important clues regarding risk of vitamin D deficiency and skin cancer. Here, we investigate whether variation in the shape of the external nose across populations has been driven by regional differences in climate. We find that variation in both nares width and alar base width appear to have experienced accelerated divergence across human populations. We also find that the geospatial distribution of nares width is correlated with temperature, and absolute humidity, but not with relative humidity. Our results support the claim that local adaptation to climate may have had a role in the evolution of nose shape differences across human populations.
sneezing causing split lips
if you sneeze suddenly when your lips are very dry, such as after a long night in a dry room, you may split your lips. to prevent this, try to wet your lips before you sneeze.
nose blocked with mucous
first blow as much out as you can, then try to drain by tilting head back and breathing in through nose as much as you can. after a while it will clear. this works by allowing the nose to clear and dry out.
factors causing dry airways
lipton pluripotent shift
blinking eyes removes contaminants
tiredness, irritability and dehydration — I wonder whether some portion of tantrums in children and adults is from dehydration…
dry airways, bed type, habitual sleeping position (high pillows, face up) increase snoring and sleep apnea
apply plasters, band–aids in a chiral form to suit the appendage — for example, on the finger, do not apply perpendicular or parallel to the length of the finger, but rather in a spiral. this shape allows the appendage to flex in its normal fashion without overflexing the plaster